SCF and APC: the Yin and Yang of cell cycle regulated proteolysis

被引：224

作者：

Peters, JM ^{[1
]}

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0955-0674(98)80119-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Progression through the cell cycle requires the activity of two ubiquitination complexes, the Skp1 -cullin-F-box-protein complex (SCF) and the anaphase-promoting complex/cyclosome (APC). Observations in the past year have revealed unexpected similarities between the SCF and the APC and have allowed detailed insight into the regulation of their activities. Both complexes are now known to exist in different forms that target: different substrates for ubiquitin-dependent proteolysis.

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页码：759 / 768

页数：10

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