Tumor escape mechanism governed by myeloid-derived suppressor cells

被引：241

作者：

Nagaraj, Srinivas ^{[1
]}

Gabrilovich, Dmitry I. ^{[1
]}

机构：

[1] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33612 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 08期

关键词：

D O I：

10.1158/0008-5472.CAN-07-6229

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

T-cell nonresponsiveness is a critical factor in immune escape and myeloid-derived suppressor cells play a major role in organizing this phenomenon. Recent findings indicate that myeloid-derived suppressor cells can induce antigen-specific CD8(+) T-cell tolerance through a posttranslation mechanism which involves modification (nitration) of CD8 and the T-cell receptor itself on the T-cell surface. Elucidation of this mechanism of T-cell tolerance offers new opportunities for therapeutic corrections of immune escape in cancer.

引用

页码：2561 / 2563

页数：3

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