A role for RKIP in cell motility

被引:12
作者
Bement, WM
机构
[1] Univ Wisconsin, Dept Zool, Madison, WI 53706 USA
[2] Univ Wisconsin, Mol & Cellular Biol Program, Madison, WI 53706 USA
来源
CHEMISTRY & BIOLOGY | 2005年 / 12卷 / 09期
关键词
D O I
10.1016/j.chembiol.2005.08.012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The target of locostatin, a small-molecule inhibitor of cell movement, has been identified as RKIP, a Raf-1 kinase modulator [1]. In addition to advancing our understanding of cell locomotion, this work represents a major landmark in the development of chemical genetics.
引用
收藏
页码:953 / 954
页数:2
相关论文
共 17 条
[1]   Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2 [J].
Aragay, AM ;
Mellado, M ;
Frade, JMR ;
Martin, AM ;
Jimenez-Sainz, MC ;
Martinez-A, C ;
Mayor, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :2985-2990
[2]   Modulation of protein-protein interactions with small organic molecules [J].
Berg, T .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (22) :2462-2481
[3]   Raf-1 regulates Rho signaling and cell migration [J].
Ehrenreiter, K ;
Piazzolla, D ;
Velamoor, V ;
Sobczak, I ;
Small, JV ;
Takeda, J ;
Leung, T ;
Baccarini, M .
JOURNAL OF CELL BIOLOGY, 2005, 168 (06) :955-964
[4]   MEK kinase activity is not necessary for Raf-1 function [J].
Hüser, M ;
Luckett, J ;
Chiloeches, A ;
Mercer, K ;
Iwobi, M ;
Giblett, S ;
Sun, XM ;
Brown, J ;
Marais, R ;
Pritchard, C .
EMBO JOURNAL, 2001, 20 (08) :1940-1951
[5]   Temporal and spatial regulation of chemotaxis [J].
Iijima, M ;
Huang, YE ;
Devreotes, P .
DEVELOPMENTAL CELL, 2002, 3 (04) :469-478
[6]  
INGLESE J, 1993, J BIOL CHEM, V268, P23735
[7]   Metastasis suppressor genes: a role for raf kinase inhibitor protein (RKIP) [J].
Keller, ET .
ANTI-CANCER DRUGS, 2004, 15 (07) :663-669
[8]   Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2 [J].
Lorenz, K ;
Lohse, MJ ;
Quitterer, U .
NATURE, 2003, 426 (6966) :574-579
[9]  
Mc Henry KT, 2002, CHEMBIOCHEM, V3, P1105, DOI 10.1002/1439-7633(20021104)3:11<1105::AID-CBIC1105>3.0.CO
[10]  
2-S