Icariin induces the Expression of Toll-like Receptor 9 in Ana-1 Murine Macrophages

被引：42

作者：

Li, Li ^{[1
]}

Peng, Lina ^{[2
]}

Miao, Jianhua ^{[1
]}

Qiu, Yafeng ^{[2
]}

Zhou, Ying ^{[3
]}

Gao, Xiaoqi ^{[2
]}

Xu, Yongli ^{[1
]}

Shi, Zixue ^{[2
]}

Shao, Donghua ^{[2
]}

Ma, Zhiyong ^{[2
]}

机构：

[1] Guangxi Bot Garden Med Plants, Nanning 530023, Peoples R China

[2] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

[3] Fisheries & Husb Sch Guangxi, Nanning 530021, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2011年 / 25卷 / 11期

关键词：

icariin; Toll-like receptor 9; Herba epimedii; innate immunity; IMMUNE-RESPONSE; INHIBITION; ANTIBODY; PATHWAY;

D O I：

10.1002/ptr.3514

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Icariin is the major pharmacologically active compound of Herba epimedii which has been used as a tonic, aphrodisiac and an antirheumatic in traditional Chinese medicine. This study analysed the effect of icariin on the expression of Toll-like receptor 9 (TLR9) which plays an important role in regulation of the innate immune response. Stimulation of Ana-1 murine macrophages with icariin induced a significant dose-dependent expression of TLR9, and its mRNA expression which increased from 3 h post-treatment was approximately fivefold that of DMSO-treated cells. Several molecules, such as myeloid differentiation factor 88, tumor necrosis factor-alpha and interleukin 6, which are involved in the TLR9 downstream signaling pathway, were also significantly up-regulated in response to icariin stimulation. Our findings demonstrated that icariin is able to induce the expression of TLR9. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：1732 / 1735

页数：4

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