Feature-size limitations of microarray technology - a critical review

被引:40
作者
Bier, FF
Kleinjung, F
机构
[1] Fraunhofer Inst Biomed Engn, Dept Mol Bioanalyt & Bioelect, D-14558 Bergholz Rehbrucke, Germany
[2] Noxxon Pharma AG, D-10234 Berlin, Germany
来源
FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY | 2001年 / 371卷 / 02期
关键词
D O I
10.1007/s002160101003
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The appeal of microarray technology is the possibility of large-scale parallel determination of a variety of variables simultaneously. Hence, microarray technologies attract the interest of both the scientific and business worlds alike. High-throughput screening has been the major focus of the utilization of microarray technologies in recent years, and has provided the strong driving force for developments in this field. DNA chip and biochip technologies have been developed as a consequence of worldwide activity in genome research. This review focuses on microarray-based analysis and emphasizes some of its principal constraints, especially detection limits.
引用
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页码:151 / 156
页数:6
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