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A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution

被引：182
作者：
Dolce, V
Scarcia, P
Iacopetta, D
Palmieri, F
机构：
[1] Univ Bari, Dept Pharmacobiol, Biochem & Mol Biol Lab, I-70125 Bari, Italy
[2] Univ Calabria, Dept Pharmacobiol, I-87036 Cosenza, Italy
[3] CNR, Inst Biomembranes & Bioenerget, I-70126 Bari, Italy
来源：
FEBS LETTERS | 2005年 / 579卷 / 03期
关键词：
ADP/ATP carrier; isoform; mitochondrial carrier; mitochondrion; transport;
D O I：
10.1016/j.febslet.2004.12.034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mitochondrial ADP/ATP carriers (AACs) catalyze the exchange of cytosolic ADP for matrix ATP. We have identified and characterized a novel member of the AAC subfamily of mitochondrial metabolite transport proteins, termed AAC4. The AAC4 gene maps to human chromosome 4q28.1, and its product AAC4 is 66-68% identical to human AAC 1-3 and is localized to mitochondria. AAC4 transcripts are exclusively present in liver, testis and brain unlike those of AAC 1-3. Consistent with its belonging to the AAC subfamily, upon heterologous expression and reconstitution into liposomes AAC4 exchanges ADP for ATP by an electrogenic antiport mechanism with high specificity and high sensitivity to carboxyatractyloside and bongkrekic acid. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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页码：633 / 637
页数：5
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