Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

被引：235

作者：

Fukumoto, Y ^{[1
]}

Matoba, T ^{[1
]}

Ito, A ^{[1
]}

Tanaka, H ^{[1
]}

Kishi, T ^{[1
]}

Hayashidani, S ^{[1
]}

Abe, K ^{[1
]}

Takeshita, A ^{[1
]}

Shimokawa, H ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka 812, Japan

来源：

HEART | 2005年 / 91卷 / 03期

关键词：

D O I：

10.1136/hrt.2003.029470

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：391 / 392

页数：2

共 5 条

[1] Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats [J].

Abe, K ;

Shimokawa, H ;

Morikawa, K ;

Uwatoku, T ;

Oi, K ;

Matsumoto, Y ;

Hattori, T ;

Nakashima, Y ;

Kaibuchi, K ;

Sueishi, K ;

Takeshita, A .

CIRCULATION RESEARCH, 2004, 94 (03) :385-393

[2] Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans [J].

Masumoto, A ;

Hirooka, Y ;

Shimokawa, H ;

Hironaga, K ;

Setoguchi, S ;

Takeshita, A .

HYPERTENSION, 2001, 38 (06) :1307-1310

[3] Primary pulmonary hypertension [J].

Runo, JR ;

Loyd, JE .

LANCET, 2003, 361 (9368) :1533-1544

[4] Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases [J].

Shimokawa, H .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2002, 39 (03) :319-327

[5] Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II [J].

Somlyo, AP ;

Somlyo, AV .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 522 (02) :177-185

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