Human high affinity, Na+-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): Gene structure and localization to chromosome 5p11-p12

被引：23

作者：

Stoffel, W ^{[1
]}

Sasse, J ^{[1
]}

Duker, M ^{[1
]}

Muller, R ^{[1
]}

Hofmann, K ^{[1
]}

Fink, T ^{[1
]}

Lichter, P ^{[1
]}

机构：

[1] DEUTSCH KREBSFORSCHUNGSZENTRUM,INST VIRUSFORSCH,D-69120 HEIDELBERG,GERMANY

来源：

FEBS LETTERS | 1996年 / 386卷 / 2-3期

关键词：

glutamate; aspartate; neurotransmitter transporter; hGLAST-1;

D O I：

10.1016/0014-5793(96)00424-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene of the human L-glutamate transporter hGLAST-1 (EAAT-1) has been isolated and characterized. The 1626 bp cDNA open reading frame (542 aa) is distributed over ten exons and at least 85 kb on chromosome 5p11-p12, The gene is unrelated to any other previously described neurotransmitter transporter gene family, but its exon/intron structure corresponds largely to that of the Na+-dependent neutral amino acid transporter ASCT-1. GLAST-1, ASCT-1 and the glutamate transporters GLT-1 and EAAC-1 have strongly similar amino acid sequences. The L-glutamate transporter gene structures might help to understand the correlation of L-glutamate reuptake in neurodegenerative disorders.

引用

页码：189 / 193

页数：5

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