Allergy and asthma

被引：199

作者：

Bochner, BS

Busse, WW

机构：

[1] Univ Wisconsin, Sch Med, Dept Med, Madison, WI 53792 USA

[2] Johns Hopkins Univ, Baltimore, MD USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2005年 / 115卷 / 05期

关键词：

Eosinophils; mast cells; smooth muscle; cysteinyl leukotrienes; asthma;

D O I：

10.1016/j.jaci.2005.02.032

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Initiation and regulation of allergic inflammation is influenced by many factors, including cell type, membrane receptors, and mediators generated. Furthermore, the altered response of targeted tissues (ie, airway smooth muscle) becomes important to the eventual expression of asthma. Finally, the genetic regulation and association of genetic polymorphisms has enhanced our understanding of host susceptibility. In this review key findings published in 2004 issues of the Journal of Allergy and Clinical Immunology are highlighted to demonstrate recent advances in these areas.

引用

收藏

页码：953 / 959

页数：7

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