DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans - A review

被引：37

作者：

Geijtenbeek, TBH ^{[1
]}

van Vliet, SJ ^{[1
]}

van Duijnhoven, GCF ^{[1
]}

Figdor, CG ^{[1
]}

van Kooyk, Y ^{[1
]}

机构：

[1] Univ Nijmegen, Dept Tumor Immunol, Med Ctr St Radboud, NL-6525 EX Nijmegen, Netherlands

来源：

PLACENTA | 2001年 / 22卷

关键词：

D O I：

10.1053/plac.2001.0674

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD-C and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development. (C) 2001 IFPA and Harcourt Publishers Ltd.

引用

页码：S19 / S23

页数：5

共 31 条

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