Neural disease:: Drosophila degenerates for a good cause

被引:19
作者
Mutsuddi, M [1 ]
Nambu, JR [1 ]
机构
[1] Univ Massachusetts, Dept Biol, Morrill Sci Ctr, Amherst, MA 01003 USA
关键词
D O I
10.1016/S0960-9822(07)00506-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Human neurodegenerative disorders are typified by late onset cell loss in specific brain regions and stereotypic neuroanatomical and behavioral aberrations. Recent studies suggest that molecular genetic approaches in Drosophila may shed important new light on conserved mechanisms underlying such disorders.
引用
收藏
页码:R809 / R811
页数:3
相关论文
共 21 条
[1]   Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons [J].
Adams, CM ;
Anderson, MG ;
Motto, DG ;
Price, MP ;
Johnson, WA ;
Welsh, MJ .
JOURNAL OF CELL BIOLOGY, 1998, 140 (01) :143-152
[2]   Cloning and characterization of the Drosophila presenilin homologue [J].
Boulianne, GL ;
LivneBar, I ;
Humphreys, JM ;
Liang, Y ;
Lin, C ;
Rogaev, E ;
StGeorgeHyslop, P .
NEUROREPORT, 1997, 8 (04) :1025-1029
[3]   SPONTANEOUS ASYMMETRIC CIRCLING BEHAVIOR IN HEMI-PARKINSONISM - A HUMAN EQUIVALENT OF THE LESIONED-CIRCLING RODENT BEHAVIOR [J].
BRACHA, HS ;
SHULTS, C ;
GLICK, SD ;
KLEINMAN, JE .
LIFE SCIENCES, 1987, 40 (11) :1127-1130
[4]   DEFECTIVE GLIA IN THE DROSOPHILA BRAIN DEGENERATION MUTANT DROP-DEAD [J].
BUCHANAN, RL ;
BENZER, S .
NEURON, 1993, 10 (05) :839-850
[5]   THE STRUCTURAL BRAIN MUTANT VACUOLAR-MEDULLA OF DROSOPHILA-MELANOGASTER WITH SPECIFIC BEHAVIORAL DEFECTS AND CELL DEGENERATION IN THE ADULT [J].
COOMBE, PE ;
HEISENBERG, M .
JOURNAL OF NEUROGENETICS, 1986, 3 (03) :135-158
[6]   Blocking apoptosis prevents blindness Drosophila retinal degeneration mutants [J].
Davidson, FF ;
Steller, H .
NATURE, 1998, 391 (6667) :587-591
[7]   A genetic screen for mutations that disrupt an auditory response in Drosophila melanogaster [J].
Eberl, DF ;
Duyk, GM ;
Perrimon, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14837-14842
[8]   Myelin mutants: Model systems for the study of normal and abnormal myelination [J].
Griffiths, IR .
BIOESSAYS, 1996, 18 (10) :789-797
[9]   Isolation and characterization of Drosophila presenilin homolog [J].
Hong, CS ;
Koo, EH .
NEUROREPORT, 1997, 8 (03) :665-668
[10]   Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development [J].
Karlin, S ;
Burge, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (04) :1560-1565