Memantine hydrochloride

被引：77

作者：

Witt, A ^{[1
]}

Macdonald, N ^{[1
]}

Kirkpatrick, P ^{[1
]}

机构：

[1] Decis Resources Inc, Waltham, MA 02453 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 02期

关键词：

D O I：

10.1038/nrd1311

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Memantine hydrochloride (Namenda; Forest/Merz), which acts to protect neurons against toxicity caused by overactivation of N-methyl-D-aspartate receptors, became the first drug to be approved by the US FDA for the treatment of moderate to severe Alzheimer's disease in October 2003, after its approval for the same indication in the European Union in 2002. What influence could this have on its market potential?

引用

页码：109 / 110

页数：2

共 8 条

[1] MEMANTINE IS A POTENT BLOCKER OF N-METHYL-D-ASPARTATE (NMDA) RECEPTOR CHANNELS [J].