Anorexia, sarcopenia, and aging

被引：203

作者：

Morley, JE

机构：

[1] St Louis Univ, Sch Med, Div Geriatr Med, St Louis, MO 63104 USA

[2] St Louis VAMC, Ctr Geriatr Res Educ & Clin, St Louis, MO USA

来源：

NUTRITION | 2001年 / 17卷 / 7-8期

关键词：

sarcopenia; weight loss; cytokines; anorexia; muscle; nutrition;

D O I：

10.1016/S0899-9007(01)00574-3

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Food intake declines throughout the life span. This physiologic anorexia of aging is caused in part by alterations of stomach-fundus compliance and release and activity of cholecystokin. In addition, the decline in testosterone in males results in elevated leptin levels that increase the anorexia. There is also evidence that cytokines play a role in the pathogenesis of anorexia and sarcopenia, thus accelerating the development of frailty in older persons. Numerous treatable causes of anorexia and weight loss exist. Depression is the most commonly diagnosed cause of pathologic weight loss in older persons. (C) Elsevier Science Inc. 2001.

引用

收藏

页码：660 / 663

页数：4

相关论文

共 65 条

[1]

Baez-Franceschi D, 1999, Z GERONTOL GERIATR, V32, P12

[2] Serum leptin in elderly people: Associations with sex hormones, insulin, and adipose tissue volumes [J].

Baumgartner, RN ;

Ross, RR ;

Waters, DL ;

Brooks, WM ;

Morley, JE ;

Montoya, GD ;

Garry, PJ .

OBESITY RESEARCH, 1999, 7 (02) :141-149

[3] Age-related changes in sex hormones affect the sex difference in serum leptin independently of changes in body fat [J].

Baumgartner, RN ;

Waters, DL ;

Morley, JE ;

Patrick, P ;

Montoya, GD ;

Garry, PJ .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1999, 48 (03) :378-384

[4] Predictors of skeletal muscle mass in elderly men and women [J].

Baumgartner, RN ;

Waters, DL ;

Gallagher, D ;

Morley, JE ;

Garry, PJ .

MECHANISMS OF AGEING AND DEVELOPMENT, 1999, 107 (02) :123-136

[5]

CHAMPMAN IM, 1998, AM J PHYSL 2, V274, pR596

[6] Evidence for the anorexia of aging: Gastrointestinal transit and hunger in healthy elderly vs young adults [J].

Clarkston, WK ;

Pantano, MM ;

Morley, JE ;

Horowitz, M ;

Littlefield, JM ;

Burton, FR .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 272 (01) :R243-R248

[7]

COOK CG, 1997, AM J PHYSIOL-REG I, V42, pR75

[8] TESTOSTERONE ENHANCES ESTRADIOLS EFFECTS ON POSTMENOPAUSAL BONE-DENSITY AND SEXUALITY [J].

DAVIS, SR ;

MCCLOUD, P ;

STRAUSS, BJG ;

BURGER, H .

MATURITAS, 1995, 21 (03) :227-236

[9] Impaired sensory functioning in elders: The relation with its potential determinants and nutritional intake [J].

de Jong, N ;

Mulder, I ;

de Graaf, C ;

van Staveren, WA .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1999, 54 (08) :B324-B331

[10] STAT signalling in the mature and aging brain [J].

De-Fraja, C ;

Conti, L ;

Govoni, S ;

Battaini, F ;

Cattaneo, E .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2000, 18 (4-5) :439-446

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