Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide

被引：12

作者：

Masuoka, Eriko ^{[1
]}

Bito, Toshinori ^{[1
]}

Shimizu, Hideki ^{[1
]}

Nishigori, Chikako ^{[1
]}

机构：

[1] Kobe Univ, Div Dermatol, Dept Internal Related, Grad Sch Med,Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE | 2011年 / 27卷 / 06期

关键词：

hydrochlorothiazide; leukomelanoderma; melanocyte; photosensitivity;

D O I：

10.1111/j.1600-0781.2011.00614.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

We report a 68-year-old Japanese man who developed photoleukomelanoderma following prolonged photosensitivity caused by hydrochlorothiazide. He showed complete recovery from the leukomelanoderma with the discontinuation of the responsive drug and with topical application of tacrolimus hydrate and corticosteroid. Histological and immunohistochemical examination revealed that there were no melanin-positive cells in the hypopigmented area, despite the presence of melanocytes. These results and the clinical course indicate that leukomelanoderma is postulated temporary dysfunction of melanocytes. We also conducted a review of previous case reports regarding drug-induced photoleukomelanoderma.

引用

页码：328 / 330

页数：3

共 5 条

[1]

THIAZIDE-INDUCED PHOTOSENSITIVITY - A STUDY OF 33 SUBJECTS [J].