Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field:: Relationship with the progression of Alzheimer's disease

被引：63

作者：

Akram, Afia ^{[1
,2
]}

Christoffel, Daniel ^{[1
]}

Rocher, Anne B. ^{[1
]}

Bouras, Constantin ^{[1
,6
]}

Koevari, Enikoe ^{[6
]}

Perl, Daniel P. ^{[3
]}

Morrison, John H. ^{[1
,4
]}

Herrmann, Francois R. ^{[5
]}

Haroutunian, Vahram ^{[2
]}

Giannakopoulos, Panteleimon ^{[6
,7
]}

Hof, Patrick R. ^{[1
,4
]}

机构：

[1] Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Pathol Neuropathol, New York, NY 10029 USA

[4] Mt Sinai Sch Med, Dept Geriatr & Adult Dev, New York, NY 10029 USA

[5] Univ Geneva, Sch Med, Dept Rehabil & Geriatr, CH-1211 Geneva, Switzerland

[6] Univ Geneva, Sch Med, Dept Psychiat, CH-1211 Geneva, Switzerland

[7] Hosp CHUV, Div Old Age Psychiat, Prilly, Switzerland

来源：

NEUROBIOLOGY OF AGING | 2008年 / 29卷 / 09期

关键词：

Alzheimer's disease; cognition; synapses; tangles;

D O I：

10.1016/j.neurobiolaging.2007.03.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta. in the CA I and CA3 fields of hippocampus and area 9 in 18 elderly individuals with various degrees of cognitive decline. The decrease in spinophilin-immunoreactivity was significantly related to both Braak neurofibrillary tangle (NFT) staging and clinical severity but not A beta deposition staging. The total number of spinophilin-immunoreactive puncta in CA I field and area 9 were significantly related to MMSE scores and predicted 23.5 and 61.9% of its variability. The relationship between total number of spinophilin-immunoreactive puncta in CA I field and MMSE scores did not persist when adjusting for Braak NFT staging. In contrast, the total number of spinophilin-immunoreactive puncta in area 9 was still significantly related to the cognitive outcome explaining an extra 9.6% of MMSE and 25.6% of the Clinical Dementia Rating scores variability. Our data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1296 / 1307

页数：12

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