Monitoring HPV type-specific prevalence over time through clinic-based surveillance: A perspective on vaccine effectiveness

被引:6
作者
Gaffga, N. H. [1 ]
Flagg, E. W. [1 ]
Weinstock, H. S. [1 ]
Shlay, J. C. [2 ]
Ghanem, K. G. [3 ]
Koutsky, L. A. [4 ]
Kerndt, P. R. [5 ]
Hsu, K. K. [6 ]
Unger, E. R. [7 ]
Datta, S. D. [1 ]
机构
[1] Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA
[2] Denver Publ Hlth, Denver, CO USA
[3] Johns Hopkins Univ, Sch Med, Baltimore, MD USA
[4] Univ Washington, Seattle, WA 98195 USA
[5] Cty Los Angeles Dept Hlth Serv, STD Program, Los Angeles, CA USA
[6] Massachusetts Dept Publ Hlth, Div STD Prevent, Boston, MA USA
[7] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Infect Dis, Div Viral Resp Dis, Chron Viral Dis Branch, Atlanta, GA 30333 USA
关键词
HPV; HPV vaccine; Clinic-based surveillance; HUMAN-PAPILLOMAVIRUS INFECTION; GENITAL WARTS; NATURAL-HISTORY; CERVICAL-CANCER; UNITED-STATES; LESIONS; IMPACT; WOMEN;
D O I
10.1016/j.vaccine.2012.01.021
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We investigated the feasibility of monitoring trends in prevalence of vaccine-preventable human papillomavirus (HPV) types in different clinic populations. We collected cervical specimens from women presenting to family planning, primary care, and sexually transmitted disease (STD) clinics for routine pap smears in five US cities during 2003-2005. We performed HPV genotyping and calculated annual type-specific prevalences; pre-vaccine era prevalence was highest for HPV 16(6.0; 95% confidence interval [CI] 5.5-6.6%) and annual prevalences for vaccine-preventable types were stable, with few exceptions, after controlling for clinic type, age group, and city. With sufficient sample size and stable population characteristics, clinic-based surveillance systems can contribute to monitoring HPV vaccine impact in the cervical screening population. Published by Elsevier Ltd.
引用
收藏
页码:1959 / 1964
页数:6
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