Oligopeptides as catalysts for asymmetric epoxidation

被引:71
作者
Kelly, DR [1 ]
Roberts, SM
机构
[1] Cardiff Univ, Sch Chem, Tatem Labs, Cardiff CF10 3AT, Wales
[2] Univ Manchester, Dept Chem, Manchester M60 1QD, Lancs, England
关键词
Weitz-Scheffer; Julia-Colonna; epoxidation; polyamino acids; PLL; polyleucine; alpha-helix; enzyme kinetics; active site model; chiral amplification; prebiotic;
D O I
10.1002/bip.20373
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oligopeptides are versatile catalysts for the enantioselective epoxidation of electron deficient alkenes, (e.g. alpha,beta-unsaturated ketones) with alkaline hydrogen peroxide. This review describes optimisation of the catalyst, substrate range, synthetic applications of the products and rationalisation of the stereoselectivity by an active site model. (C) 2005 Wiley Periodicals, Inc.
引用
收藏
页码:74 / 89
页数:16
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