Synthesis of isogranulatimides A and B analogues possessing a 7-azaindole unit instead of an indole moiety

被引：25

作者：

Hugon, B

Pfeiffer, B

Renard, P

Prudhomme, M ^{[1
]}

机构：

[1] Univ Clermont Ferrand, CNRS, Synth & Etud Syst Interet Biol UMR 6504, F-63177 Clermont Ferrand, France

[2] Les Labs SERVIER, F-92415 Courbevoie, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 24期

关键词：

G2 checkpoint inhibitors; isogranulatimide; rebeccamycin;

D O I：

10.1016/S0040-4039(03)00924-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a new family of isogranulatimides analogues is described in which a 7-azaindole replaces the indole moiety. The key step is the photocyclization of the aza didemnimide intermediates which leads to two isomeric analogues of isogranulatimides A and B. A derivative bearing a carbohydrate part linked to the azaindole via a beta-N-glycosidic bond was also prepared. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4607 / 4611

页数：5

共 21 条

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