Antidiabetic effects of quercetin in streptozocin-induced diabetic rats

被引:456
作者
Vessal, M
Hernmati, M
Vasei, M
机构
[1] Shiraz Univ Med Sci, Dept Biochem, Shiraz 71345, Iran
[2] Shiraz Univ Med Sci, Dept Pathol, Shiraz 71345, Iran
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 2003年 / 135卷 / 03期
关键词
cholesterol; diabetes; glucose tolerance; hepatic glucokinase; pancreatic islets; quercetin; streptozocin; triglycerides;
D O I
10.1016/S1532-0456(03)00140-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Effects of the intraperitoneal injection of quercetin in streptozocin-induced diabetic and normal rats were investigated and compared. Although quercetin had no effect on plasma glucose level of normal animals, it significantly and dose-dependently decreased the plasma glucose level of streptozocin-induced diabetic rats. Glucose tolerance tests of the diabetic animals approached those of normal rats, their plasma cholesterol and triglycerides were reduced significantly, while their hepatic glucokinase activity was significantly increased upon quercetin treatment. In normal rats, quercetin did not affect the glucose tolerance test, but resulted in an increase of plasma cholesterol and triglycerides and a decrease in hepatic glucokinase activity. No significant pathologic changes were noted in hepatocytes or kidney tubules and glomeruli. while the number of pancreatic islets significantly increased in both treated normal and diabetic groups. It is concluded that quercetin, a flavonoid with antioxidant properties brings about the regeneration of the pancreatic islets and probably increases insulin release in streptozocin-induced diabetic rats; thus exerting its beneficial antidiabetic effects. However, it may be of little value in normoglycemic animals. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:357 / 364
页数:8
相关论文
共 24 条
[1]   Activation of Reg gene, a gene for insulin-producing β-cell regeneration:: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation [J].
Akiyama, T ;
Takasawa, S ;
Nata, K ;
Kobayashi, S ;
Abe, M ;
Shervani, NJ ;
Ikeda, T ;
Nakagawa, K ;
Unno, M ;
Matsuno, S ;
Okamoto, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (01) :48-53
[2]  
ALLAIN CC, 1974, CLIN CHEM, V20, P470
[3]   ASSESSMENT OF THE ANTIDIABETIC ACTIVITY OF EPICATECHIN IN STREPTOZOTOCIN-DIABETIC AND SPONTANEOUSLY DIABETIC BB/E RATS [J].
BONE, AJ ;
HII, CST ;
BROWN, D ;
SMITH, W ;
HOWELL, SL .
BIOSCIENCE REPORTS, 1985, 5 (03) :215-221
[4]   FUNCTIONAL BETA-CELL REGENERATION IN THE ISLETS OF PANCREAS IN ALLOXAN INDUCED DIABETIC RATS BY (-)-EPICATECHIN [J].
CHAKRAVARTHY, BK ;
GUPTA, S ;
GODE, KD .
LIFE SCIENCES, 1982, 31 (24) :2693-2697
[5]  
CHAKRAVARTHY BK, 1982, LANCET, V2, P272
[6]  
CHAKRAVARTHY BK, 1981, LANCET, V2, P759
[7]   FACTORS UNDERLYING SIGNIFICANT UNDERESTIMATIONS OF GLUCOKINASE ACTIVITY IN CRUDE LIVER EXTRACTS - PHYSIOLOGICAL IMPLICATIONS OF HIGHER CELLULAR-ACTIVITY [J].
DAVIDSON, AL ;
ARION, WJ .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1987, 253 (01) :156-167
[8]   Plant-derived phenolic antioxidants [J].
Duthie, G ;
Crozier, A .
CURRENT OPINION IN LIPIDOLOGY, 2000, 11 (01) :43-47
[9]   Review of the biology of quercetin and related bioflavonoids [J].
Formica, JV ;
Regelson, W .
FOOD AND CHEMICAL TOXICOLOGY, 1995, 33 (12) :1061-1080
[10]  
FOSSATI P, 1982, CLIN CHEM, V28, P2077