Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance

被引：29

作者：

Crimmins, N. A.

Martin, L. J.

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Endocrinol, Cincinnati, OH 45229 USA

[2] Univ Cincinnati, Sch Med, Cincinnati, OH USA

来源：

OBESITY REVIEWS | 2007年 / 8卷 / 05期

关键词：

adiponectin receptor; ADIPOR1; ADIPOR2; insulin resistance;

D O I：

10.1111/j.1467-789X.2007.00348.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adiponectin plays an important role in insulin sensitivity via adiponectin receptor 1 and 2 signalling. To date, six genetic association studies have examined the role of polymorphisms in the adiponectin receptor 1 and 2 genes (ADIPOR1 and ADIPOR2) in insulin resistance and type 2 diabetes. These studies are summarized in this review along with unpublished data from the authors. In addition, these polymorphism studies are used to illustrate some of the potential pitfalls and reasons for poor reproducibility of findings in genetic association studies.

引用

收藏

页码：419 / 423

页数：5

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