Two modes of ligand recognition by TLRs

被引：65

作者：

Brodsky, Igor ^{[1
]}

Medzhitov, Ruslan ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst & Sect Immunol, New Haven, CT 06520 USA

来源：

CELL | 2007年 / 130卷 / 06期

关键词：

D O I：

10.1016/j.cell.2007.09.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll- like receptors ( TLRs) are membrane- bound sensors that detect and respond to microbial infection. Two studies in Cell, one in this issue, reveal how TLRs recognize their ligands. Kim etal. ( 2007) recently reported the structure of TLR4 bound to the accessory protein MD- 2 and its antagonist, the drug eritoran. In this issue, Jin et al. ( 2007) describe the crystal structure of a complex between TLR1, TLR2, and a lipopeptide ligand.

引用

页码：979 / 981

页数：5

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