Viral Shedding Duration of Pandemic Influenza A H1N1 Virus during an Elementary School Outbreak-Pennsylvania, May-June 2009

被引：25

作者：

Bhattarai, Achuyt ^{[1
]}

Villanueva, Julie ^{[1
,2
]}

Palekar, Rakhee S. ^{[1
]}

Fagan, Ryan ^{[1
]}

Sessions, Wendy ^{[1
]}

Winter, Joern ^{[1
]}

Berman, LaShondra ^{[1
]}

Lute, James ^{[3
]}

Leap, Rebecca ^{[1
]}

Marchbanks, Tiffany ^{[3
]}

Sodha, Samir V. ^{[1
]}

Moll, Maria ^{[3
]}

Xu, Xiyan ^{[1
]}

Fry, Alicia ^{[1
]}

Fiore, Anthony ^{[1
]}

Ostroff, Stephen ^{[3
]}

Swerdlow, David L. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA USA

[2] Battelle Mem Inst, Atlanta, GA USA

[3] Penn Dept Hlth, Harrisburg, PA 17108 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 52卷

关键词：

INFECTION;

D O I：

10.1093/cid/ciq026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report shedding duration of 2009 pandemic influenza A (pH1N1) virus from a school-associated outbreak in Pennsylvania during May through June 2009. Outbreak-associated students or household contacts with influenza-like illness (ILI) onset within 7 days of interview were recruited. Nasopharyngeal specimens, collected every 48 hours until 2 consecutive nonpositive tests, underwent real-time reverse transcriptase polymerase chain reaction (rRT-PCR) and culture for pH1N1 virus. Culture-positive specimens underwent virus titrations. Twenty-six (median age, 8 years) rRT-PCR-positive persons, for pH1N1 virus, were included in analysis. Median shedding duration from fever onset by rRT-PCR was 6 days (range, 1-13) and 5 days (range, 1-7) by culture. Following fever resolution virus was isolated for a median of 2 days (range, 0-5). Highest and lowest virus titers detected, 2 and 5 days following fever onset, were 3.2 and 1.2 log(10) TCID(50)/mL respectively. Overall, shedding duration in children and adults were similar to seasonal influenza viruses.

引用

页码：S102 / S108

页数：7

共 15 条

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