Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata

被引：130

作者：

Dao, Trong Tuan ^{[1
]}

Nguyen, Phi Hung ^{[1
]}

Lee, Hong Sik ^{[2
]}

Kim, Eunhee ^{[2
]}

Park, Junsoo ^{[3
]}

Lim, Seong Il ^{[4
]}

Oh, Won Keun ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Project Team BK21, 375 Seosuk Dong, Kwangju 501759, South Korea

[2] Choong Ang Vaccine Lab, Taejon 305348, South Korea

[3] Yonsei Univ, Div Biol Sci & Technol, Wonju 220100, South Korea

[4] Korea Food Res Inst, Tradit Food Res Grp, Songnam 463746, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 01期

关键词：

Glycyrrhiza inflata; Licochalcone G; Influenza A; Novel influenza H1N1; Neuraminidase inhibitors; Oseltamivir resistance; VIRUS; FLAVONOIDS; PURIFICATION; FLAVANONES; ACID;

D O I：

10.1016/j.bmcl.2010.11.016

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The emergence of highly pathogenic influenza A virus strains, such as the new H1N1 swine influenza (novel influenza), represents a serious threat to global human health. During our course of an anti-influenza screening program on natural products, one new licochalcone G(1) and seven known (2-8) chalcones were isolated as active principles from the acetone extract of Glycyrrhiza inflata. Compounds 3 and 6 without prenyl group showed strong inhibitory effects on various neuraminidases from influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, the efficacy of oseltamivir with the presence of compound 3 (5 mu M) was increased against H274Y neuraminidase. This evidence of synergistic effect makes this inhibitor to have a potential possibility for control of pandemic infection by oseltamivir-resistant influenza virus. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：294 / 298

页数：5

共 25 条

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