Mechanisms of Vascular Complications in Prediabetes

被引：58

作者：

Milman, Sofiya ^{[2
]}

Crandall, Jill P. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Diabet Clin Trials Unit, Diabet Res & Training Ctr, Div Endocrinol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Div Endocrinol, Montefiore Med Ctr, Bronx, NY 10467 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2011年 / 95卷 / 02期

关键词：

Prediabetes; Cardiovascular disease; Microvascular complications; Mechanisms; IMPAIRED GLUCOSE-TOLERANCE; ENDOTHELIUM-DEPENDENT VASODILATION; CORONARY-HEART-DISEASE; CHRONIC KIDNEY-DISEASE; PLASMINOGEN-ACTIVATOR INHIBITOR-1; TYPE-2; DIABETES-MELLITUS; FASTING PLASMA-GLUCOSE; NECROSIS-FACTOR-ALPHA; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE;

D O I：

10.1016/j.mcna.2010.11.004

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Although the state of prediabetes is defined by its role as a diabetes risk factor, it also carries a significant risk of cardiovascular disease, independent of progression to diabetes. Typical diabetic microvascular complications also occur, albeit at low rates, in prediabetes. There is evidence that both glucose-related and glucose-independent mechanisms contribute to these vascular complications. Effective preventive strategies will likely require control of glycemia, as well as other metabolic risk factors. This article reviews some of the proposed mechanisms for the vascular complications of the prediabetic state.

引用

页码：309 / +

页数：18

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