NetSeed: a network-based reverse-ecology tool for calculating the metabolic interface of an organism with its environment

被引:37
作者
Carr, Rogan [1 ]
Borenstein, Elhanan [1 ,2 ,3 ]
机构
[1] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
[2] Univ Washington, Dept Comp Sci & Engn, Seattle, WA 98195 USA
[3] Santa Fe Inst, Santa Fe, NM 87501 USA
关键词
LARGE-SCALE ORGANIZATION; EVOLUTION; TOPOLOGY;
D O I
10.1093/bioinformatics/btr721
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
NetSeed is a web tool and Perl module for analyzing the topology of metabolic networks and calculating the set of exogenously acquired compounds. NetSeed is based on the seed detection algorithm, developed and validated in previous studies. Availability: The NetSeed web-based tool, open-source Perl module, examples and documentation are freely available online at: http://depts.washington.edu/elbogs/NetSeed.
引用
收藏
页码:734 / 735
页数:2
相关论文
共 18 条
[1]  
Aho A. V., 1974, The design and analysis of computer algorithms
[2]   Biological networks: The tinkerer as an engineer [J].
Alon, U .
SCIENCE, 2003, 301 (5641) :1866-1867
[3]   Large-scale reconstruction and phylogenetic analysis of metabolic environments [J].
Borenstein, Elhanan ;
Kupiec, Martin ;
Feldman, Marcus W. ;
Ruppin, Eytan .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (38) :14482-14487
[4]   Topological Signatures of Species Interactions in Metabolic Networks [J].
Borenstein, Elhanan ;
Feldman, Marcus W. .
JOURNAL OF COMPUTATIONAL BIOLOGY, 2009, 16 (02) :191-200
[5]   Graph-Based Analysis of the Metabolic Exchanges between Two Co-Resident Intracellular Symbionts, Baumannia cicadellinicola and Sulcia muelleri, with Their Insect Host, Homalodisca coagulata [J].
Cottret, Ludovic ;
Milreu, Paulo Vieira ;
Acuna, Vicente ;
Marchetti-Spaccamela, Alberto ;
Stougie, Leen ;
Charles, Hubert ;
Sagot, Marie-France .
PLOS COMPUTATIONAL BIOLOGY, 2010, 6 (09)
[6]   The large-scale organization of the bacterial network of ecological co-occurrence interactions [J].
Freilich, Shiri ;
Kreimer, Anat ;
Meilijson, Isacc ;
Gophna, Uri ;
Sharan, Roded ;
Ruppin, Eytan .
NUCLEIC ACIDS RESEARCH, 2010, 38 (12) :3857-3868
[7]   Decoupling Environment-Dependent and Independent Genetic Robustness across Bacterial Species [J].
Freilich, Shiri ;
Kreimer, Anat ;
Borenstein, Elhanan ;
Gophna, Uri ;
Sharan, Roded ;
Ruppin, Eytan .
PLOS COMPUTATIONAL BIOLOGY, 2010, 6 (02)
[8]   Metabolic-network-driven analysis of bacterial ecological strategies [J].
Freilich, Shiri ;
Kreimer, Anat ;
Borenstein, Elhanan ;
Yosef, Nir ;
Sharan, Roded ;
Gophna, Uri ;
Ruppin, Eytan .
GENOME BIOLOGY, 2009, 10 (06)
[9]   Functional cartography of complex metabolic networks [J].
Guimerà, R ;
Amaral, LAN .
NATURE, 2005, 433 (7028) :895-900
[10]   Pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii, studied in twins [J].
Hansen, Elizabeth E. ;
Lozupone, Catherine A. ;
Rey, Federico E. ;
Wu, Meng ;
Guruge, Janaki L. ;
Narra, Aneesha ;
Goodfellow, Jonathan ;
Zaneveld, Jesse R. ;
McDonald, Daniel T. ;
Goodrich, Julia A. ;
Heath, Andrew C. ;
Knight, Rob ;
Gordon, Jeffrey I. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 :4599-4606