Dendritic cell biology and cancer therapy

被引：97

作者：

Whiteside, TL ^{[1
]}

Odoux, C ^{[1
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Hillman Canc Ctr, Pittsburgh, PA 15213 USA

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2004年 / 53卷 / 03期

关键词：

human dendritic cells; vaccines; cancer; antigen presentation;

D O I：

10.1007/s00262-003-0468-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dendritic cells (DCs) are nature's best antigen-presenting cells. They possess attributes that allow them to effectively fulfill the requirements for priming/activating T cells and mediating tumor-specific immune responses. In this review, emphasis is placed on those aspects of DC biology that best illustrate their usefulness in immunotherapy of cancer. Culture, maturation, and polarization conditions for human DC are discussed, as are strategies for antigen-loading of DCs and for their delivery to patients with cancer. A concise recommendation for monitoring of DC-based vaccination trails is provided.

引用

页码：240 / 248

页数：9

共 40 条

[1] Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].

Albert, ML ;

Sauter, B ;

Bhardwaj, N .

NATURE, 1998, 392 (6671) :86-89

[2] Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes [J].

Albert, ML ;

Pearce, SFA ;

Francisco, LM ;

Sauter, B ;

Roy, P ;

Silverstein, RL ;

Bhardwaj, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (07) :1359-1368

[3] Antigen-presenting cells - Experimental and clinical studies of dendritic cells [J].

Austyn, JM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (04) :S146-+

[4] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[5]

Banchereau J, 1997, TRANSFUS SCI, V18, P313

[6] Maturation and trafficking of monocyte-derived dendritic cells in monkeys: Implications for dendritic cell-based vaccines [J].

Barratt-Boyes, SM ;

Zimmer, MI ;

Harshyne, LA ;

Meyer, EM ;

Watkins, SC ;

Capuano, S ;

Murphey-Corb, M ;

Falo, LD ;

Donnenbrg, AD .

JOURNAL OF IMMUNOLOGY, 2000, 164 (05) :2487-2495

[7] Dendritic cell biology and regulation of dendritic cell trafficking by chemokines [J].

Caux, C ;

Ait-Yahia, S ;

Chemin, K ;

de Bouteiller, O ;

Dieu-Nosjean, MC ;

Homey, B ;

Massacrier, C ;

Vanbervliet, B ;

Zlotnik, A ;

Vicari, A .

SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 2000, 22 (04) :345-369

[8] CD34(+) hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha [J].

Caux, C ;

Vanbervliet, B ;

Massacrier, C ;

DezutterDambuyant, C ;

deSaintVis, B ;

Jacquet, C ;

Yoneda, K ;

Imamura, S ;

Schmitt, D ;

Banchereau, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :695-706

[9] Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation [J].

Cella, M ;

Scheidegger, D ;

PalmerLehmann, K ;

Lane, P ;

Lanzavecchia, A ;

Alber, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :747-752

[10] Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity [J].

Celluzzi, CM ;

Mayordomo, JI ;

Storkus, WJ ;

Lotze, MT ;

Falo, LD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (01) :283-287

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