Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart

被引：121

作者：

Anderson, Ethan J. ^{[2
,3
,4
]}

Katunga, Lalage A. ^{[2
,4
]}

Willis, Monte S. ^{[1
,5
]}

机构：

[1] Univ N Carolina, Dept Med Pathol & Lab Med, McAlllister Heart Inst, Chapel Hill, NC 27599 USA

[2] E Carolina Univ, Dept Pharmacol & Toxicol, Greenville, NC USA

[3] E Carolina Univ, Dept Cardiovasc Sci, Greenville, NC USA

[4] E Carolina Univ, E Carolina Diabet & Obes Inst, Greenville, NC USA

[5] Univ N Carolina, Dept Pathol, Chapel Hill, NC 27599 USA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2012年 / 39卷 / 02期

基金：

美国国家卫生研究院;

关键词：

aldehydes; cardiac hypertrophy; diabetes; heart failure; ischaemia; lipid peroxidation products; mitochondria; INDUCED MYOCARDIAL DYSFUNCTION; ALDEHYDE DEHYDROGENASE 2; ALPHA-KETOGLUTARATE DEHYDROGENASE; RAT-LIVER MITOCHONDRIA; CYTOCHROME-C-OXIDASE; OXIDATIVE STRESS; PEROXIDIZED CARDIOLIPIN; CARDIOVASCULAR-DISEASE; OXIDIZED PHOSPHOLIPIDS; CARDIAC MITOCHONDRIA;

D O I：

10.1111/j.1440-1681.2011.05641.x

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

1. The heart is a highly oxidative organ in which cardiomyocyte turnover is virtually absent, making it particularly vulnerable to accumulation of lipid peroxidation products (LPP) formed as a result of oxidative damage.

引用

页码：179 / 193

页数：15

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