Genes "Waiting" for recruitment by the adaptive immune system: The insights from amphioxus

被引:51
作者
Yu, CL
Dong, ML
Wu, XK
Li, SG
Huang, SF
Su, J
Wei, JW
Shen, Y
Mou, CY
Xie, XJ
Lin, JH
Yuan, SC
Yu, XS
Yu, YH
Du, JC
Zhang, SC
Peng, XX
Xiang, MQ
Xu, AL
机构
[1] Sun Yat Sen Univ, Dept Biochem, Coll Life Sci, State Key Lab Biocontrol,Open Lab Marine Funct Ge, Guangzhou 510275, Peoples R China
[2] Ocean Univ China, Dept Marine Biotechnol, Qingdao, Peoples R China
[3] Xiamen Univ, Sch Life Sci, Xiamen, Peoples R China
[4] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
关键词
D O I
10.4049/jimmunol.174.6.3493
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
in seeking evidence of the existence of adaptive immune system (AIS) in ancient chordate, cDNA clones of six libraries from a protochordate, the Chinese amphioxus, were sequenced. Although the key molecules such as TCR, MHC, Ig, and RAG in AIS have not been identified from our database, we demonstrated in this study the extensive molecular evidence for the presence of genes homologous to many genes that are involved in AIS directly or indirectly, including some of which may represent the putative precursors of vertebrate AIS-related genes. The comparative analyses of these genes in different model organisms revealed the different fates of these genes during evolution. Their gene expression pattern suggested that the primitive digestive system is the pivotal place of the origin and evolution of the AIS. Our studies support the general statement that AIS appears after the jawless/jawed vertebrate split. However our study further reveals the fact that AIS is in its twilight in amphioxus and the evolution of the molecules in amphioxus are waiting for recruitment by the emergence of AIS.
引用
收藏
页码:3493 / 3500
页数:8
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