Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats

被引:60
作者
Ito, Norihisa
Ohishi, Mitsuru
Yamamoto, Koichi
Tatara, Yuji
Shiota, Atsushi
Hayashi, Norihiro
Komai, Norio
Yanagitani, Yoshihiro
Rakugi, Hiromi
Ogihara, Toshio
机构
[1] Osaka Univ, Grad Sch Med, Dept Geriatr Med, Suita, Osaka 5650871, Japan
[2] Kawasaki Med Coll, Dept Internal Med, Kurashiki, Okayama, Japan
关键词
aging SHR; hypertrophy; ACE inhibition; angiotensin antagonists; oxidative stress;
D O I
10.1016/j.amjhyper.2007.02.004
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Background: Many experiments using young hypertensive animal models support the evidence that angiotensin-converting enzyme inhibitor or angiotensin receptor type 1 blocker attenuates the progression of cardiac hypertrophy. However, it is still unclear whether inhibiting the renin-angiotensin system can reverse age-related cardiac hypertrophy. To clarify the role of renin-angiotensin system inhibition in naturally advanced myocardial hypertrophy we treated spontaneously hypertensive, aging rats with an angiotensin-converting enzyme inhibitor or an angiotensin receptor type 1 blocker. Methods: We used osmotic pumps to deliver the blood-pressure reducers temocaprilat, olmesartan, hydralazine, or saline for 4 weeks. Results: Heart and body weights were significantly C, reduced in animals treated with temocaprilat or olmesartan compared with animals treated with hydralazine or saline. Histologic myocyte size and cardiac fibrosis were significantly attenuated by temocaprilat or olmesartan. Real-time polymerase chain reaction (PCR) revealed that temocaprilat or olmesartan suppressed expression of cardiac transforming growth factor-beta 1 and fibroblast growth factor-2 mRNA, a marker of cardiac fibrosis. Cardiac and systemic oxidative stress assessed by 8-isoprostane levels was significantly reduced in animals treated with temocaprilat or olmesartan compared with hydralazine-treated or saline-treated rats. Renin-angiotensin system inhibition reduced cardiac expression of NAD(P)H oxidative components p22phox, p47phox, and gp91phox. Conclusions: Renin-angiotensin system inhibition can reverse age-related, advanced cardiac hypertrophy. The mechanism of reversal is partly due to suppression of cardiac oxidative stress. Am J Hypertens 2007;20: 792-799 (c) 2007 American Journal of Hypertension, Ltd.
引用
收藏
页码:792 / 799
页数:8
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