Low maternal concentrations of soluble vascular endothelial growth factor receptor-2 in preeclampsia and small for gestational age

被引：58

作者：

Chaiworapongsa, Tinnakorn ^{[1
,2
,3
]}

Romero, Roberto ^{[1
,2
,4
]}

Gotsch, Francesca ^{[1
,2
]}

Espinoza, Jimmy ^{[1
,2
,3
]}

Nien, Jyh Kae ^{[1
,2
]}

Goncalves, Luis ^{[1
,2
,3
]}

Edwin, Samuel ^{[1
,2
]}

Kim, Yeon Mee ^{[1
,2
,5
]}

Erez, Offer ^{[1
,2
]}

Kusanovic, Juan Pedro ^{[1
,2
]}

Pineles, Beth L. ^{[1
,2
]}

Papp, Zoltan ^{[6
]}

Hassan, Sonia ^{[1
,2
,3
]}

机构：

[1] Wayne State Univ, Hutzel Womens Hosp, Perinatol Res Branch, NICHD,NIH,DHHS, Detroit, MI 48201 USA

[2] NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD USA

[3] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA

[4] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI USA

[5] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA

[6] Semmelweis Univ, Dept Obstet & Gynecol 1, H-1085 Budapest, Hungary

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2008年 / 21卷 / 01期

关键词：

small for gestational age; intrauterine growth restriction; preeclampsia; sVEGFR-2; KDR; pregnancy;

D O I：

10.1080/14767050701831397

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives. Preeclampsia is considered an anti-angiogenic state. A role for the anti-angiogenic factors soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and soluble endoglin in preeclampsia has been proposed. Soluble vascular endothelial growth factor receptor-2 (sVEGFR-2) has been detected in human plasma, and the recombinant form of this protein has anti-angiogenic activity. There is a paucity of information about maternal plasma sVEGFR-2 concentrations in patients with preeclampsia and those without preeclampsia with small for gestational age (SGA) fetuses. This study was conducted to determine whether: (1) plasma sVEGFR-2 concentration changes throughout pregnancy; and (2) preeclampsia and SGA are associated with abnormalities in the maternal plasma concentration of sVEGFR-2. Study design. This cross-sectional study included non-pregnant women (n=40), women with normal pregnancies (n=135), women with an SGA fetus (n=53), and women with preeclampsia (n=112). SGA was defined as an ultrasound-estimated fetal weight below the 10th percentile for gestational age that was confirmed by neonatal birth weight. Plasma concentrations of sVEGFR-2 were determined by ELISA. Results. (1) There was no significant difference in the mean plasma concentration of sVEGFR-2 between non-pregnant women and those with normal pregnancies (p=0.8); (2) patients with preeclampsia and those without preeclampsia with SGA fetuses had a lower mean plasma concentration of sVEGFR-2 than that of women with normal pregnancies (p0.001 for both); and (3) there was no significant difference in the mean plasma concentration of sVEGFR-2 between patients with preeclampsia and those without preeclampsia with SGA (p=0.9). Conclusions. Preeclampsia and SGA are associated with low plasma concentrations of sVEGFR-2. One interpretation of the findings is that plasma sVEGFR-2 concentration could reflect endothelial cell function.

引用

页码：41 / 52

页数：12

共 136 条

[1] A single local injection of recombinant VEGF receptor 2 but not of tie2 inhibits retinal neovascularization in the mouse [J].