pH-triggered thermally responsive polymer core-shell nanoparticles for drug delivery

被引：343

作者：

Soppimath, KS ^{[1
]}

Tan, DCW ^{[1
]}

Yang, YY ^{[1
]}

机构：

[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 03期

关键词：

D O I：

10.1002/adma.200401057

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel polymer core-shell nanoparticles that exhibited a pH-dependent lower critical solution temperature (LCST) have been synthesized. The nanoparticles displayed stable structure in a nominal physiological environment but deformed and precipitated in an acidic environment, thereby releasing the enclosed drug molecules (see Figure). The nanoparticles would make a promising carrier for targeting drugs to tumor tissues or cell interiors where the environment is characteristically acidic.

引用

页码：318 / +

页数：7

共 17 条

[1] Molar mass control of poly(N-isopropylacrylamide) and poly(acrylic acid) in aqueous polymerizations initiated by redox initiators based on persulfates
Bokias, G
Durand, A
Hourdet, D
[J]. MACROMOLECULAR CHEMISTRY AND PHYSICS, 1998, 199 (07) : 1387 - 1392
[2] Thermally responsive core-shell nanoparticles self-assembled from cholesteryl end-capped and grafted polyacrylamides: drug incorporation and in vitro release
Chaw, CS
Chooi, KW
Liu, XM
Tan, CW
Wang, L
Yang, YY
[J]. BIOMATERIALS, 2004, 25 (18) : 4297 - 4308
[3] GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH
CHEN, GH
HOFFMAN, AS
[J]. NATURE, 1995, 373 (6509) : 49 - 52
[4] Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate)
Chung, JE
Yokoyama, M
Yamato, M
Aoyagi, T
Sakurai, Y
Okano, T
[J]. JOURNAL OF CONTROLLED RELEASE, 1999, 62 (1-2) : 115 - 127
[5] THE PY SCALE OF SOLVENT POLARITIES
DONG, DC
WINNIK, MA
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1984, 62 (11): : 2560 - 2565
[6] Current status of pH-sensitive liposomes in drug delivery
Drummond, DC
Zignani, M
Leroux, JC
[J]. PROGRESS IN LIPID RESEARCH, 2000, 39 (05) : 409 - 460
[7] THE NEUROLEPTIC ACTIVITY OF HALOPERIDOL INCREASES AFTER ITS SOLUBILIZATION IN SURFACTANT MICELLES - MICELLES AS MICROCONTAINERS FOR DRUG TARGETING
KABANOV, AV
CHEKHONIN, VP
ALAKHOV, VY
BATRAKOVA, EV
LEBEDEV, AS
MELIKNUBAROV, NS
ARZHAKOV, SA
LEVASHOV, AV
MOROZOV, GV
SEVERIN, ES
KABANOV, VA
[J]. FEBS LETTERS, 1989, 258 (02) : 343 - 345
[8] Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K
Harada, A
Nagasaki, Y
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) : 113 - 131
[9] Conformational change of poly(N-isopropylacrylamide) during the coil-globule transition investigated by attenuated total reflection/infrared spectroscopy and density functional theory calculation
Katsumoto, Y
Tanaka, T
Sato, H
Ozaki, Y
[J]. JOURNAL OF PHYSICAL CHEMISTRY A, 2002, 106 (14) : 3429 - 3435
[10] Polymeric micelle for tumor pH and folate-mediated targeting
Lee, ES
Na, K
Bae, YH
[J]. JOURNAL OF CONTROLLED RELEASE, 2003, 91 (1-2) : 103 - 113

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