Optimizing transport of metabolites through large channels: Molecular sieves with and without binding

被引:136
作者
Berezhkovskii, AM
Bezrukov, SM [1 ]
机构
[1] NICHHD, Math & Stat Comp Lab, Div Biosci, Ctr Informat Technol,NIH, Bethesda, MD 20892 USA
[2] NICHHD, Lab Phys & Struct Biol, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1529/biophysj.104.057588
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Using a diffusion model of molecules moving through a pore, we rationalize why biological channels have an affinity for the molecules they have evolved to translocate.
引用
收藏
页码:L17 / L19
页数:3
相关论文
共 11 条
[1]   Channel-facilitated membrane transport: Average lifetimes in the channel [J].
Berezhkovskii, AM ;
Pustovoit, MA ;
Bezrukov, SM .
JOURNAL OF CHEMICAL PHYSICS, 2003, 119 (07) :3943-3951
[2]   Channel-facilitated membrane transport: Transit probability and interaction with the channel [J].
Berezhkovskii, AM ;
Pustovoit, MA ;
Bezrukov, SM .
JOURNAL OF CHEMICAL PHYSICS, 2002, 116 (22) :9952-9956
[3]   Particle number fluctuations in a membrane channel [J].
Bezrukov, SM ;
Berezhkovskii, AM ;
Pustovoit, MA ;
Szabo, A .
JOURNAL OF CHEMICAL PHYSICS, 2000, 113 (18) :8206-8211
[4]   Solute uptake through general porins [J].
Delcour, AH .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2003, 8 :D1055-D1071
[5]   Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway [J].
Dutzler, R ;
Wang, YF ;
Rizkallah, PJ ;
Rosenbusch, JP ;
Schirmer, T .
STRUCTURE, 1996, 4 (02) :127-134
[6]   EFFECT OF ROTATION ON DIFFUSION-CONTROLLED RATE OF LIGAND-PROTEIN ASSOCIATION [J].
HILL, TL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (12) :4918-4922
[7]   Transport of maltodextrins through maltoporin: A single-channel study [J].
Kullman, L ;
Winterhalter, M ;
Bezrukov, SM .
BIOPHYSICAL JOURNAL, 2002, 82 (02) :803-812
[8]   Designed to penetrate: Time-resolved interaction of single antibiotic molecules with bacterial pores [J].
Nestorovich, EM ;
Danelon, C ;
Winterhalter, M ;
Bezrukov, SM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :9789-9794
[9]   Molecular basis of bacterial outer membrane permeability revisited [J].
Nikaido, H .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2003, 67 (04) :593-+
[10]   ATP transport through a single mitochondrial channel, VDAC, studied by current fluctuation analysis [J].
Rostovtseva, TK ;
Bezrukov, SM .
BIOPHYSICAL JOURNAL, 1998, 74 (05) :2365-2373