A role for flavin monooxygenase-like enzymes in auxin biosynthesis

被引:931
作者
Zhao, YD
Christensen, SK
Fankhauser, C
Cashman, JR
Cohen, JD
Weigel, D
Chory, J [1 ]
机构
[1] Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA
[2] Salk Inst Biol Studies, Plant Biol Lab, La Jolla, CA 92037 USA
[3] Human Biomol Res Inst, San Diego, CA 92121 USA
[4] Univ Minnesota, Dept Hort Sci, St Paul, MN 55108 USA
关键词
D O I
10.1126/science.291.5502.306
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Although auxin is known to regulate many processes in plant development and has been studied for over a century, the mechanisms whereby plants produce it have remained elusive. Here we report the characterization of a dominant Arabidopsis mutant,yucca, which contains elevated Levels of free auxin. YUCCA encodes a flavin monooxygenase-like enzyme and belongs to a family that includes at Least nine other homologous Arabidopsis genes, a subset of which appears to have redundant functions, Results from tryptophan analog feeding experiments and biochemical assays indicate that YUCCA catalyzes hydroxylation of the amino group of tryptamine, a rate-limiting step in tryptophan-dependent auxin biosynthesis.
引用
收藏
页码:306 / 309
页数:4
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