The regulation and activation potential of autoreactive B cells

被引：11

作者：

Fields, ML ^{[1
]}

Seo, SJ ^{[1
]}

Nish, SA ^{[1
]}

Tsai, JH ^{[1
]}

Caton, AJ ^{[1
]}

Erikson, J ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

IMMUNOLOGIC RESEARCH | 2003年 / 27卷 / 2-3期

关键词：

autoimmunity; tolerance; B cell; T cell; dendritic cell; T-independent; T regulation; CpG;

D O I：

10.1385/IR:27:2-3:219

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune-prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicle, but also leads to secretion of anti-dsDNA autoantibodies. Intriguingly, if T regulatory cells are provided along with T helper cells, the antibody response of anti-dsDNA B cells is diminished. We have also found that T-independent stimulation with CpG oligodeoxynucleotides leads to the proliferation and enhanced recovery of anti-dsDNA B cells in vitro. These data suggest that control of anti-dsDNA antibody production may rely on elements from both the innate and adaptive arms of the immune system.

引用

页码：219 / 233

页数：15

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