CTLA-4 and its role in autoimmune thyroid disease

被引：109

作者：

Chistiakov, DA ^{[1
]}

Turakulov, RI

机构：

[1] Katholieke Univ Leuven, Aquat Ecol Lab, B-3000 Louvain, Belgium

[2] Australian Natl Univ, John Curtin Sch Med Res, Ctr Bioinformat Sci, Canberra, ACT 2601, Australia

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2003年 / 31卷 / 01期

关键词：

D O I：

10.1677/jme.0.0310021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation of the CTLA4 locus. Population genetics data strongly suggest a role for the CTLA4 region in susceptibility to AITD. However, further functional studies are required to understand the significance of CTLA4 polymorphisms in the pathogenic mechanism of AITD. Journal of Molecular Endocrinology (2003).

引用

页码：21 / 36

页数：16

共 115 条

[1] Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients [J].

Akamizu, T ;

Sale, MM ;

Rich, SS ;

Hiratani, H ;

Noh, JY ;

Kanamoto, N ;

Saijo, M ;

Miyamoto, Y ;

Saito, Y ;

Nakao, K ;

Bowden, DW .

THYROID, 2000, 10 (10) :851-858

[2] MHC class II region, CTLA4 gene, and ophthalmopathy in patients with Graves' disease [J].

Allahabadia, A ;

Heward, JM ;

Nithiyananthan, R ;

Gibson, SM ;

Reuser, TTQ ;

Dodson, PM ;

Franklyn, JA ;

Gough, SCL .

LANCET, 2001, 358 (9286) :984-985

[3] Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves disease and Hashimoto's thyroiditis) in the Japanese population [J].

Awata, T ;

Kurihara, S ;

Iitaka, M ;

Takei, S ;

Inoue, I ;

Ishii, C ;

Negishi, K ;

Izumida, T ;

Yoshida, Y ;

Hagura, R ;

Kuzuya, N ;

Kanazawa, Y ;

Katayama, S .

DIABETES, 1998, 47 (01) :128-129

[4] Genetic markers in diagnosis and prediction of relapse in Graves' disease [J].

Badenhoop, K ;

Donner, H ;

Braun, J ;

Siegmund, T ;

Rau, H ;

Usadel, KH .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 1996, 104 :98-100

[5]

Balzano C, 1992, Int J Cancer Suppl, V7, P28

[6] Linkage analysis of candidate genes in autoimmune thyroid disease: 1. Selected immunoregulatory genes [J].

Barbesino, G ;

Tomer, Y ;

Concepcion, E ;

Davies, TF ;

Greenberg, DA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (05) :1580-1584

[7]

Barnes R, 1997, DIABETOLOGIA, V40, P194

[8] Management of Graves' ophthalmopathy: Reality and perspectives [J].

Bartalena, L ;

Pinchera, A ;

Marcocci, C .

ENDOCRINE REVIEWS, 2000, 21 (02) :168-199

[9] Association of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism and non-genetic factors with Graves' ophthalmopathy in European and Japanese populations [J].

Bednarczuk, T ;

Hiromatsu, Y ;

Fukutani, T ;

Jazdzewski, K ;

Miskiewicz, P ;

Osikowska, M ;

Nauman, J .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 148 (01) :13-18

[10] CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis [J].

Braun, J ;

Donner, H ;

Siegmund, T ;

Walfish, PG ;

Usadel, KH ;

Badenhoop, K .

TISSUE ANTIGENS, 1998, 51 (05) :563-566

← 1 2 3 4 5 6 7 8 9 10 →