Rho family GTPases: The cytoskeleton and beyond

被引:255
作者
Symons, M
机构
关键词
D O I
10.1016/0968-0004(96)10022-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Until recently, members of the Rho family of GTPases were considered primarily to be regulators of the distinct structures making up the actin cytoskeleton. Several Rho GTPases have now also been shown to play an important role in cell transformation. In addition, Cdc42, Rac and Rho activate transcription, providing a possible mechanism for their role in growth control.
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页码:178 / 181
页数:4
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共 45 条
[1]   Identification of a putative target for Rho as the serine-threonine kinase protein kinase N [J].
Amano, M ;
Mukai, H ;
Ono, Y ;
Chihara, K ;
Matsui, T ;
Hamajima, Y ;
Okawa, K ;
Iwamatsu, A ;
Kaibuchi, K .
SCIENCE, 1996, 271 (5249) :648-650
[2]   Two GTPases, cdc42 and rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome [J].
Aspenstrom, P ;
Lindberg, U ;
Hall, A .
CURRENT BIOLOGY, 1996, 6 (01) :70-75
[3]   PROTEINS REGULATING RAS AND ITS RELATIVES [J].
BOGUSKI, MS ;
MCCORMICK, F .
NATURE, 1993, 366 (6456) :643-654
[4]   A CONSERVED BINDING MOTIF DEFINES NUMEROUS CANDIDATE TARGET PROTEINS FOR BOTH CDC42 AND RAC GTPASES [J].
BURBELO, PD ;
DRECHSEL, D ;
HALL, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (49) :29071-29074
[5]   A FOCAL ADHESION FACTOR DIRECTLY LINKING INTRACELLULARLY MOTILE LISTERIA-MONOCYTOGENES AND LISTERIA-IVANOVII TO THE ACTIN-BASED CYTOSKELETON OF MAMMALIAN-CELLS [J].
CHAKRABORTY, T ;
EBEL, F ;
DOMANN, E ;
NIEBUHR, K ;
GERSTEL, B ;
PISTOR, S ;
TEMMGROVE, CJ ;
JOCKUSCH, BM ;
REINHARD, M ;
WALTER, U ;
WEHLAND, J .
EMBO JOURNAL, 1995, 14 (07) :1314-1321
[6]   ASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL INACTIVATION OF CALCINEURIN [J].
CHANG, HY ;
TAKEI, K ;
SYDOR, AM ;
BORN, T ;
RUSNAK, F ;
JAY, DG .
NATURE, 1995, 376 (6542) :686-690
[7]   GTPASE CASCADES CHOREOGRAPHING CELLULAR BEHAVIOR - MOVEMENT, MORPHOGENESIS, AND MORE [J].
CHANT, J ;
STOWERS, L .
CELL, 1995, 81 (01) :1-4
[8]   THE SMALL GTP-BINDING PROTEIN-RHO REGULATES A PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE IN MAMMALIAN-CELLS [J].
CHONG, LD ;
TRAYNORKAPLAN, A ;
BOKOCH, GM ;
SCHWARTZ, MA .
CELL, 1994, 79 (03) :507-513
[9]   THE SMALL GTP-BINDING PROTEINS RAC1 AND CDC42 REGULATE THE ACTIVITY OF THE JNK/SAPK SIGNALING PATHWAY [J].
COSO, OA ;
CHIARIELLO, M ;
YU, JC ;
TERAMOTO, H ;
CRESPO, P ;
XU, NG ;
MIKI, T ;
GUTKIND, JS .
CELL, 1995, 81 (07) :1137-1146
[10]   STE20-LIKE PROTEIN-KINASES ARE REQUIRED FOR NORMAL LOCALIZATION OF CELL-GROWTH AND FOR CYTOKINESIS IN BUDDING YEAST [J].
CVRCKOVA, F ;
DEVIRGILIO, C ;
MANSER, E ;
PRINGLE, JR ;
NASMYTH, K .
GENES & DEVELOPMENT, 1995, 9 (15) :1817-1830