Association of plasma homocysteine with serum interleukin-6 and C-peptide levels in patients with type 2 diabetes

被引:32
作者
Araki, A [1 ]
Hosoi, T
Orimo, H
Ito, H
机构
[1] Tokyo Metropolitan Geriatr Hosp, Dept Endocrinol, Tokyo 1730015, Japan
[2] Tokyo Metropolitan Tama Geriatr Hosp, Tokyo 1898511, Japan
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2005年 / 54卷 / 06期
关键词
D O I
10.1016/j.metabol.2005.02.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hyperhomocysteinemia is an independent risk factor for atherosclerotic disease. Because serum markers of inflammation and the metabolic syndrome are also associated with atherosclerotic disease and insulin resistance, we investigated whether plasma homocysteine (Hcy) levels were associated with serum markers of inflammation and factors of metabolic syndrome in 223 elderly patients with type 2 diabetes mellitus. The levels of plasma Hcy and serum interleukin-6 (IL-6), high-sensitivity C-reactive protein, and C-peptide were measured. The C677T mutation of methylenetetrahydrofolate reductase (MTHFR) gene was detected using the polymerase chain reaction-restriction fragment length polymorphism method. The number of abnormal metabolic factors (presence of diabetes, blood pressure >= 130/85 mm Hg, triglycerides >= 150 mg/dL, high-density lipoprotein cholesterol < 35 mg/dL (men) or < 39 mg/dL (women), or body mass index > 25 kg/m(2)) was assessed. Elevated plasma Hey levels correlated significantly with serum IL-6 (r = 0.25, P < .001), C-peptide (r = 0.22, P < .0 1), and the number of abnormal metabolic factors (r = 0.20, P < .01), but not with C-reactive protein. Multiple linear regression analysis revealed that log-transformed IL-6, serum C-peptide. vitamin B-12, and creatinine were significant determinants of plasma Hcy levels. The correlation between Hcy and IL-6 levels was strongest in those with TT genotype of C677T MTHFR among 3 genotypes. The association between plasma Hcy and serum IL-6 levels supports the hypothesis that the activation of innate immunity is involved in the pathogenesis of arteriosclerosis in patients with diabetes mellitus who are homozygous for the TT genotype of C677T MTHFR. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:809 / 814
页数:6
相关论文
共 33 条
[1]   PLASMA HOMOCYSTEINE CONCENTRATIONS IN JAPANESE PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS - EFFECT OF PARENTERAL METHYLCOBALAMIN TREATMENT [J].
ARAKI, A ;
SAKO, Y ;
ITO, H .
ATHEROSCLEROSIS, 1993, 103 (02) :149-157
[2]   DETERMINATION OF FREE AND TOTAL HOMOCYSTEINE IN HUMAN-PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION [J].
ARAKI, A ;
SAKO, Y .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 422 :43-52
[3]  
Araki A., 2002, GERIATR GERONTOL INT, V2, P206, DOI [10.1046/j.1444-1586.2002.00047.x, DOI 10.1046/J.1444-1586.2002.00047.X]
[4]  
ARAKI A, 2002, GERIAT GERONTOL INT, V3, P15
[5]   Interleukin-6 serum levels and genotypes influence the risk for myocardial infarction [J].
Bennet, AM ;
Prince, JA ;
Fei, GZ ;
Lyrenäs, L ;
Huang, YH ;
Wiman, B ;
Frostegård, J ;
de Faire, U .
ATHEROSCLEROSIS, 2003, 171 (02) :359-367
[6]   Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease [J].
Christensen, B ;
Frosst, P ;
LussierCacan, S ;
Selhub, J ;
Goyette, P ;
Rosenblatt, DS ;
Genest, J ;
Rozen, R .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (03) :569-573
[7]   HYPERHOMOCYSTEINEMIA - AN INDEPENDENT RISK FACTOR FOR VASCULAR-DISEASE [J].
CLARKE, R ;
DALY, L ;
ROBINSON, K ;
NAUGHTEN, E ;
CAHALANE, S ;
FOWLER, B ;
GRAHAM, I .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (17) :1149-1155
[8]   ELEVATED PLASMA HOMOCYST(E)INE CONCENTRATION AS A POSSIBLE INDEPENDENT RISK FACTOR FOR STROKE [J].
COULL, BM ;
MALINOW, MR ;
BEAMER, N ;
SEXTON, G ;
NORDT, F ;
DEGARMO, P .
STROKE, 1990, 21 (04) :572-576
[9]   Effect of homocysteine on cytokine production by human endothelial cells and monocytes [J].
Dalal, S ;
Parkin, SM ;
Homer-Vanniasinkam, S ;
Nicolaou, A .
ANNALS OF CLINICAL BIOCHEMISTRY, 2003, 40 :534-541
[10]   Homocysteine augments cytokine-induced chemokine expression in human vascular smooth muscle cells: Implications for atherogenesis [J].
Desai, A ;
Lankford, HA ;
Warren, JS .
INFLAMMATION, 2001, 25 (03) :179-186