Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli

被引：334

作者：

Fralick, JA

机构：

[1] Department of Microbiology, Texas Tech University, Health Sciences Center, Lubbock

来源：

JOURNAL OF BACTERIOLOGY | 1996年 / 178卷 / 19期

关键词：

D O I：

10.1128/jb.178.19.5803-5805.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A study examining the influence of TolC on AcrA, AcrR, and MarR1 mutants indicates that functional TolC is required for the operation of the AcrAB efflux system and for the expression of the Mar phenotype. That the effect of TolC on the AcrAB pump is not regulatory in nature is shown by studies measuring the influence of a tolC::Tn10 insertion mutation on the expression of an acrA::lacZ reporter fusion. These results are compatible with the hypothesis that TolC is a component of the AcrAB efflux complex.

引用

收藏

页码：5803 / 5805

页数：3

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