A highly polymorphic CA repeat marker at the human interleukin 6 receptor (IL6R) locus

被引：19

作者：

Tsukamoto, K

Ohta, N

Shirai, Y

Emi, M

机构：

[1] Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, Kawasaki, Kanagawa 2118533, Japan

[2] Nippon Med Sch, Dept Orthoped, Tokyo 113, Japan

来源：

JOURNAL OF HUMAN GENETICS | 1998年 / 43卷 / 04期

关键词：

interleukin; 6; dinucleotide repeat; inflammation; osteoclast; bone resorption;

D O I：

10.1007/s100380050095

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

A polymorphic dinucleotide (CA) sequence was isolated from a genomic clone containing the human interleukin 6 receptor (IL6R) gene. High heterozygosity (0.81) makes this polymorphism a useful marker in the genetic study of disorders affecting the inflammation process and bone resorption.

引用

页码：289 / 290

页数：2

共 6 条

[1]

KLUCK PMC, 1993, HUM GENET, V90, P542

[2]

MANOLAGAS SC, 1995, BONE, V17, P63

[3]

Application of DNA markers to clinical genetics [J].