Effect of pravastatin in mildly hypercholesterolemic young men on serum matrix metalloproteinases

被引：36

作者：

Kalela, A

Laaksonen, R

Lehtimäki, T

Koivu, TA

Höyhtyä, M

Janatuinen, T

Pöllänen, P

Vesalainen, R

Saikku, P

Knuuti, J

Nikkari, ST ^{[1
]}

机构：

[1] Tampere Univ, Sch Med, Dept Biochem Med, FIN-33014 Tampere, Finland

[2] Tampere Univ Hosp, Dept Internal Med, Tampere, Finland

[3] Univ Helsinki, Dept Clin Pharmacol, SF-00250 Helsinki, Finland

[4] Tampere Univ Hosp, Dept Clin Chem, Lab Atherosclerosis Genet, Ctr Lab Med, Tampere, Finland

[5] Diabor Ltd, Oulu, Finland

[6] Turku Univ, Turku Pet Ctr, Turku, Finland

[7] Natl Publ Hlth Inst, Oulu, Finland

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 88卷 / 02期

关键词：

D O I：

10.1016/S0002-9149(01)01616-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pravastatin decreases serum MMP-9 concentration in clinically healthy men. This may reflect reduction of nonsymptomatic chronic arterial inflammation.

引用

页码：173 / +

页数：4

共 16 条

[1] HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages [J].

Bellosta, S ;

Via, D ;

Canavesi, M ;

Pfister, P ;

Fumagalli, R ;

Paoletti, R ;

Bernini, F .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (11) :1671-1678

[2] HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis [J].

Bustos, C ;

Hernández-Presa, MA ;

Ortego, M ;

Tuñón, J ;

Ortega, L ;

Pérez, F ;

Díaz, C ;

Hernández, G ;

Egido, J .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (07) :2057-2064

[3] Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis [J].

de Maat, MPM ;

Jukema, JW ;

Ye, S ;

Zwinderman, AH ;

Moghaddam, PH ;

Beekman, M ;

Kastelein, JJP ;

van Boven, AJ ;

Bruschke, AVG ;

Humphries, SE ;

Kluft, C ;

Henney, AM .

AMERICAN JOURNAL OF CARDIOLOGY, 1999, 83 (06) :852-856

[4] INCREASED EXPRESSION OF MATRIX METALLOPROTEINASES AND MATRIX-DEGRADING ACTIVITY IN VULNERABLE REGIONS OF HUMAN ATHEROSCLEROTIC PLAQUES [J].

GALIS, ZS ;

SUKHOVA, GK ;

LARK, MW ;

LIBBY, P .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (06) :2493-2503

[5] MACROPHAGE FOAM CELLS FROM EXPERIMENTAL ATHEROMA CONSTITUTIVELY PRODUCE MATRIX-DEGRADING PROTEINASES [J].

GALIS, ZS ;

SUKHOVA, GK ;

KRANZHOFER, R ;

CLARK, S ;

LIBBY, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (02) :402-406

[6] EFFECTS OF LIPID-LOWERING BY PRAVASTATIN ON PROGRESSION AND REGRESSION OF CORONARY-ARTERY DISEASE IN SYMPTOMATIC MEN WITH NORMAL TO MODERATELY ELEVATED SERUM-CHOLESTEROL LEVELS - THE REGRESSION GROWTH EVALUATION STATIN STUDY (REGRESS) [J].

JUKEMA, JW ;

BRUSCHKE, AVG ;

VANBOVEN, AJ ;

REIBER, JHC ;

BAL, ET ;

ZWINDERMAN, AH ;

JANSEN, H ;

BOERMA, GJM ;

VANRAPPARD, FM ;

LIE, KI .

CIRCULATION, 1995, 91 (10) :2528-2540

[7]

Kalela A, 2000, EUR J CLIN INVEST, V30, P99

[8] Statins and C-reactive protein [J].

Kluft, C ;

de Maat, MPM ;

Leuven, JAG ;

van Loon, BJP ;

Mohrschladt, MF .

LANCET, 1999, 353 (9160) :1274-1274

[9] Inhibition of proinflammatory cytokine production by pravastatin [J].

Rosenson, RS ;

Tangney, CC ;

Casey, LC .

LANCET, 1999, 353 (9157) :983-984

[10] THE KUOPIO ATHEROSCLEROSIS PREVENTION STUDY (KAPS) - EFFECT OF PRAVASTATIN TREATMENT ON LIPIDS, OXIDATION RESISTANCE OR LIPOPROTEINS, AND ATHEROSCLEROTIC PROGRESSION [J].

SALONEN, R ;

NYYSSONEN, K ;

PORKKALASARATAHO, E ;

SALONEN, JT .

AMERICAN JOURNAL OF CARDIOLOGY, 1995, 76 (09) :C34-C39

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