Rewiring of the yeast transcriptional network through the evolution of motif usage

被引：215

作者：

Ihmels, J

Bergmann, S

Gerami-Nejad, M

Yanai, I

McClellan, M

Berman, J

Barkai, N ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel

[3] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA

来源：

SCIENCE | 2005年 / 309卷 / 5736期

关键词：

D O I：

10.1126/science.1113833

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent experiments revealed large-scale differences in the transcription programs of related species, yet little is known about the genetic basis underlying the evolution of gene expression and its contribution to phenotypic diversity. Here we describe a large-scale modulation of the yeast transcription program that is connected to the emergence of the capacity for rapid anaerobic growth. Genes coding for mitochondrial and cytoplasmic ribosomal proteins display a strongly correlated expression pattern in Candida, albicans, but this correlation is lost in the fermentative yeast Saccharomyces cerevisiae. We provide evidence that this change in gene expression is connected to the loss of a specific cis-regulatory element from dozens of genes following the apparent whole-genome duplication event. Our results shed new light on the genetic mechanisms underlying the large-scale evolution of transcriptional networks.

引用

页码：938 / 940

页数：3

共 14 条

[1] Similarities and differences in genome-wide expression data of six organisms [J].