Antiviral activity of tenofovir (PMPA) against nucleoside-resistant clinical HIV samples

被引：70

作者：

Miller, MD

Margot, NA

Hertogs, K

Larder, B

Miller, V

机构：

[1] Gilead Sci Inc, Foster City, CA 94404 USA

[2] Virco, Mechelen, Belgium

[3] Virco, Cambridge, England

[4] Univ Frankfurt, D-6000 Frankfurt, Germany

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期

关键词：

D O I：

10.1081/NCN-100002483

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of the lamivudine-associated M184V RT mutation increases tenofovir susceptibility in multiple HIV genotypes. Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. HIV with common forms of zidovudine and lamivudine resistance are susceptible to tenofovir, corroborating phase II clinical results demonstrating the activity of tenofovir DF in treatment-experienced patients.

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页码：1025 / 1028

页数：4

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