Mechanisms of resistance to ErbB-targeted cancer therapeutics

被引：23

作者：

Wang, Qiang ^{[1
]}

Greene, Mark I. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2008年 / 118卷 / 07期

关键词：

D O I：

10.1172/JCI36260

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The ErbB receptors, such as EGFR, have been intensely pursued as targets for cancer therapeutics. However, a large percentage of patients who are initially responsive to ErbB-targeted therapies experience tumor recurrence and become refractory to therapy. In this issue of the JCI, Guix et al. demonstrate that downregulation of IGF-binding protein 3 (IGFBP-3) and -4, the negative regulators of IGF-I receptor signaling, contributes to the resistance of human squamous cell carcinomas to the EGFR inhibitor gefitinib (see the related article beginning on page 2609). Understanding the mechanisms involved in the resistance of some tumors to ErbB-targeted molecules may provide guidelines for developing more efficient therapeutic approaches'.

引用

页码：2389 / 2392

页数：4

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