Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development

被引：60

作者：

Kammermeier, L

Leemans, R

Hirth, F

Flister, S

Wenger, U

Walldorf, U

Gehring, WJ

Reichert, H

机构：

[1] Univ Basel, Bioctr, Pharmactr, Inst Zool, CH-4056 Basel, Switzerland

[2] Univ Basel, Bioctr, Pharmactr, Dept Cell Biol, CH-4056 Basel, Switzerland

[3] Univ Hohenheim, Inst Genet, D-70593 Stuttgart, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 103卷 / 1-2期

关键词：

Drosophila; central nervous system development; Pax genes; eyeless; twin of eyeless; brain development; embryo; neurogenesis; immunocytochemistry; mutants; RNA interference; misexpression; confocal microscopy; evolution;

D O I：

10.1016/S0925-4773(01)00328-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We analyzed the expression and function of eyeless (ey) and twin of eyeless (toy) in the embryonic central nervous system (CNS) of Drosophila. Both genes are differentially expressed in specific neuronal subsets (but not in glia) in every CNS neuromere, and in the brain, specific cell populations co-expressing both proteins define a longitudinal domain which is intercalated between broad exclusive expression domains of ey and toy. Studies of genetic null alleles and dsRNA interference did not reveal any gross neuroanatomical effects of rv, ro?, or ey/toy elimination in the embryonic CNS. In contrast, targeted misexpression of ey, but not of toy, resulted in profound axonal abnormalities in the embryonic ventral nerve cord and brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：71 / 78

页数：8

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