Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection

被引：28

作者：

Seckert, Christof K. ^{[1
]}

Renzaho, Angelique ^{[1
]}

Reddehase, Matthias J. ^{[1
]}

Grzimek, Natascha K. A. ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Virol, D-55131 Mainz, Germany

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2008年 / 197卷 / 02期

关键词：

bone marrow; chimerism; cytomegalovirus; hematopoiesis; hematopoietic stem cell transplantation (HSCT); latency; latent infection; quantitative PCR; recurrent infection; stromal cells; reactivation; sex-mismatched HSCT; tdy gene;

D O I：

10.1007/s00430-008-0094-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hematopoietic stem cell transplantation (HSCT) bears a risk of reactivating latent cytomegalovirus (CMV) in either the transplanted hematopoietic donor cells or in parenchymal and stromal tissue cells of the immunocompromised recipient, or in both. While reactivated human CMV in recipients of organ transplantations is frequently the virus variant of the donor, this is not usually the case in HSCT recipients. Here we have used experimental sex-mismatched HSCT in the BALB/c mouse model to test if latent murine CMV from CMV-immune donors is transmitted with bone marrow cells to naive immunocompromised recipients.

引用

页码：251 / 259

页数：9

共 48 条

[1] The current status of hematopoietic cell transplantation [J].

Appelbaum, FR .

ANNUAL REVIEW OF MEDICINE-SELECTED TOPICS IN THE CLINICAL SCIENCES, 2003, 54 :491-512

[2]

Bain M, 2006, CYTOMEGALOVIRUSES: MOLECULAR BIOLOGY AND IMMUNOLOGY, P167

[3] LUNGS ARE A MAJOR ORGAN SITE OF CYTOMEGALOVIRUS LATENCY AND RECURRENCE [J].

BALTHESEN, M ;

MESSERLE, M ;

REDDEHASE, MJ .

JOURNAL OF VIROLOGY, 1993, 67 (09) :5360-5366

[4] THE ESTABLISHMENT OF CYTOMEGALOVIRUS LATENCY IN ORGANS IS NOT LINKED TO LOCAL VIRUS PRODUCTION DURING PRIMARY INFECTION [J].

BALTHESEN, M ;

DREHER, L ;

LUCIN, P ;

REDDEHASE, MJ .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :2329-2336

[5]

Balthesen Monika, 1994, Croatian Medical Journal, V35, P19

[6] Peripheral blood CD14+ cells from healthy subjects carry a circular conformation of latent cytomegalovirus genome [J].

Bolovan-Fritts, CA ;

Mocarski, ES ;

Wiedeman, JA .

BLOOD, 1999, 93 (01) :394-398

[7] RESCUE OF MYELOID LINEAGE-COMMITTED PREPROGENITOR CELLS FROM CYTOMEGALOVIRUS-INFECTED BONE-MARROW STROMA [J].

BUSCH, FW ;

MUTTER, W ;

KOSZINOWSKI, UH ;

REDDEHASE, MJ .

JOURNAL OF VIROLOGY, 1991, 65 (02) :981-984

[8]

Digel M, 2006, CYTOMEGALOVIRUSES: MOLECULAR BIOLOGY AND IMMUNOLOGY, P445

[9] Evidence against a key role for transforming growth factor-β1 in cytomegalovirus-induced bone marrow aplasia [J].

Dobonici, M ;

Podlech, J ;

Steffens, HP ;

Maiberger, S ;

Reddehase, MJ .

JOURNAL OF GENERAL VIROLOGY, 1998, 79 :867-876

[10]

Emery VC, 1998, MG VIROLOGY, V21, P288

← 1 2 3 4 5 →