Copper-catalyzed coupling of tertiary aliphatic amines with terminal alkynes to propargylamines via C-H activation

被引：119

作者：

Niu, Mingyu ^{[1
]}

Yin, Zhengming ^{[2
]}

Fu, Hua ^{[1
]}

Jiang, Yuyang ^{[1
,3
]}

Zhao, Yufen ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist educ, Beijing 100084, Peoples R China

[2] Zhengzhou Univ, Dept Chem, Key Lab Chem Biol & Organ Chem, Zhengzhou 450052, Henan Province, Peoples R China

[3] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol, Shenzhen 518057, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 10期

关键词：

D O I：

10.1021/jo800279j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a convenient and efficient method for coupling of tertiary aliphatic amines with terminal alkynes to propargylamines via C-H activation. The protocol uses CuBr as the catalyst, NBS as the free radical initiator, CH3CN as the solvent, and the alkynylation was selectively performed on the methyl of tertiary aliphatic amines at 80 degrees C. This is an economical and practical method for the synthesis of propargylamines.

引用

页码：3961 / 3963

页数：3

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