VDR activation of intracellular signaling pathways in skeletal muscle

被引：81

作者：

Boland, Ricardo L. ^{[1
]}

机构：

[1] Univ Nacl Sur, Dept Biol Bioquim & Farm, RA-8000 Bahia Blanca, Buenos Aires, Argentina

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2011年 / 347卷 / 1-2期

关键词：

VDR; Muscle; Cell signaling; 1; alpha; 25(OH)(2)D-3; Non-genomic effects; VITAMIN-D-RECEPTOR; PROTEIN-KINASE-C; OPERATED CA2+ INFLUX; TYROSINE PHOSPHORYLATION; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; MEMBRANE-RECEPTOR; 1,25-DIHYDROXYVITAMIN-D3 RECEPTORS; 25(OH)(2)-VITAMIN D-3; PLASMA-MEMBRANE; BINDING-PROTEIN;

D O I：

10.1016/j.mce.2011.05.021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The purpose of this article is to review the activation of signal transduction pathways in skeletal muscle cells by the hormone 1 alpha,25(OH)(2)-vitamin D-3[1 alpha,25(OH)(2)D-3], focusing on the role of the vitamin D receptor (VDR). The hormone induces fast, non transcriptional responses, involving stimulation of the transmembrane second messenger systems adenylyl cyclase/cAMP/PKA, PLC/DAG + IP3/PKC, Ca2+ messenger system and MAPK cascades. Short treatment with 1 alpha,25(OH)(2)D-3 induces reverse translocation of the VDR from the nucleus to plasma membranes. Accordingly, a complex is formed in the caveolae between the VDR and TRCP3, integral protein of capacitative Ca2+ entry (CCE), suggesting an association between both proteins and a functional role of the VDR in 1 alpha,25(OH)(2)D-3 activation of CCE. Stimulation of tyrosine phosphorylation cascades by 1 alpha,25(OH)(2)D-3 have demonstrated the formation of complexes between Src and the VDR. Through these mechanisms, 1 alpha,25(OH)(2)D-3 plays an important function in contractility and myogenesis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：11 / 16

页数：6

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