Biodistribution of chitosan-based magnetite suspensions for targeted hyperthermia in ICR mice

被引：10

作者：

Kim, DH ^{[1
]}

Lee, SH

Im, KH

Kim, KN

Kim, KM

Kim, KD

Park, H

Shim, IB

Lee, YK

机构：

[1] Yonsei Univ, Coll Dent, Brain Korea Project Med Sci 21, Dept & Res Inst Dent Biomat & Bioengn, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Dent, Human Identif Res Ctr, Dept Oral & Maxillofacial Radiol, Seoul 120752, South Korea

[3] Kookmin Univ, Dept Phys Elect, Seoul 136702, South Korea

来源：

IEEE TRANSACTIONS ON MAGNETICS | 2005年 / 41卷 / 10期

关键词：

biomedical materials; cancer; hyperthermia; magnetic liquids;

D O I：

10.1109/TMAG.2005.854857

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Magnetite and the chitosan-based magnetite suspensions were synthesized by spray-coprecipitation. In the 2 wt% chitosan-based magnetite suspension, the zeta-potential value was lower value at 5.6 mV relative to other concentrations of magnetic suspension. The chitosan-based magnetic suspension with a zeta potential close to zero showed increased circulation time in biodistribution of Institute of Cancer Research mice.

引用

页码：4158 / 4160

页数：3

共 8 条

[1] Magnetic chitosan microspheres:: preparation and characterization [J].

Denkbas, EB ;

Kiliçay, E ;

Birlikseven, C ;

Öztürk, E .

REACTIVE & FUNCTIONAL POLYMERS, 2002, 50 (03) :225-232

[2]

DOUGLAS SJ, 1987, CRIT REV THER DRUG, V3, P233

[3] Thermal ablation of tumors using magnetic nanoparticles - An in vivo feasibility study [J].

Hilger, I ;

Hiergeist, R ;

Hergt, R ;

Winnefeld, K ;

Schubert, H ;

Kaiser, WA .

INVESTIGATIVE RADIOLOGY, 2002, 37 (10) :580-586

[4] Culture of primary rat hepatocytes within porous chitosan scaffolds [J].

Li, JL ;

Pan, JL ;

Zhang, LG ;

Guo, XJ ;

Yu, YT .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 67A (03) :938-943

[5] SUPERPARAMAGNETIC PARTICLES AS ORAL CONTRAST-MEDIUM IN MR IMAGING OF MALIGNANT-LYMPHOMA [J].

LONNEMARK, M ;

HEMMINGSSON, A ;

BACHGANSMO, T ;

HAGBERG, H ;

MAGNUSSON, A ;

GUNDERSEN, HG ;

NYMAN, R .

ACTA RADIOLOGICA, 1991, 32 (03) :232-238

[6] Design of microencapsulated chitosan microspheres for colonic drug delivery [J].

Lorenzo-Lamosa, ML ;

Remunan-Lopez, C ;

Vila-Jato, JL ;

Alonso, MJ .

JOURNAL OF CONTROLLED RELEASE, 1998, 52 (1-2) :109-118

[7]

MASASHIGE S, 2002, J BIOSCI BIOENG, V94, P606

[8] Surface-modified biodegradable albumin nano- and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats [J].

Roser, M ;

Fischer, D ;

Kissel, T .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1998, 46 (03) :255-263

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