Proteolytic control of growth factor availability

被引：131

作者：

Rifkin, DB ^{[1
]}

Mazzieri, R ^{[1
]}

Munger, JS ^{[1
]}

Noguera, I ^{[1
]}

Sung, J ^{[1
]}

机构：

[1] NYU Med Ctr, Dept Cell Biol, New York, NY 10016 USA

来源：

APMIS | 1999年 / 107卷 / 01期

关键词：

plasminogen activator (PA); transforming growth factor beta (TGF-beta); proteases;

D O I：

10.1111/j.1699-0463.1999.tb01529.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most growth factors are released from cells in a form that does not permit immediate interaction with their high affinity receptors. An important mechanism for presentation of these released latent growth factors is activation by the plasminogen activator - plasmin system. The involvement of this system in the biology of Transforming Growth Factor-beta (TGF-beta) is reviewed.

引用

收藏

页码：80 / 85

页数：6

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