Effects of acute D-CPPene on mesoaccumbens dopamine responses to nicotine in the rat

被引：16

作者：

Balfour, DJK

Birrell, CE

Moran, RJ

Benwell, MEM

机构：

[1] Department of Pharmacology, University of Dundee Medical School, Ninewells Hospital

[2] Dept. of Therapeut. and Pharmacology, Queen's University, Whitla Medical Building, Belfast BT 97 BL

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 316卷 / 2-3期

基金：

英国惠康基金;

关键词：

nicotine; D-CPPene (SDZ EAA 494; 3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid); sensitization; dopamine; mesoaccumbens; locomotor activity;

D O I：

10.1016/S0014-2999(96)00792-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Acute administration of the NMDA receptor antagonist, D-CPPene (SDZ EAA 494; 3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid; 2 mg/kg), abolished (P < 0.01) the sensitised mesoaccumbens dopamine response to nicotine (0.4 mg/kg) measured using in vivo microdialysis, but not the increased locomotor activity, observed in rats pretreated with nicotine prior to the test day. D-CPPene enhanced (P < 0.01) the mesoaccumbens dopamine response, but not the locomotor response, to acute nicotine given to drug-naive rats. The data suggest that sensitised mesoaccumbens dopamine responses to nicotine involve co-stimulation of NMDA receptors but that this effect is not closely related to sensitisation of the locomotor response to the drug.

引用

页码：153 / 156

页数：4

共 12 条

[1]

BALFOUR DJK, 1990, PSYCHOTROPIC DRUGS A, P453

[2] THE EFFECTS OF ACUTE AND REPEATED NICOTINE TREATMENT ON NUCLEUS-ACCUMBENS DOPAMINE AND LOCOMOTOR-ACTIVITY [J].